Antibody‐dependent complement activity is associated not only with autoimmune morbidity,
but also with antitumor efficacy. In infectious disease, both recombinant monoclonal …

In April 2012, a group of nephrologists organized a consensus conference in Cambridge
(UK) on type II membranoproliferative glomerulonephritis and decided to use a new …

C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence
showing isolated or dominant C3 staining, indicating hyperactivity of the alternative …

In recent years, a substantial body of experimental and clinical work has been devoted to C3
glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the …

The glomerulus is often the prime target of dysregulated alternative pathway (AP) activation.
In particular, AP activation is the key driver of two severe kidney diseases: atypical hemolytic …

C3 glomerulopathy (C3G) is a rare set of kidney diseases with 2 patterns: C3
glomerulonephritis (C3GN) and dense deposit disease. Pathogenesis of both diseases is …

Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury that may
be primary or secondary to infections, autoimmune diseases and haematological disorders …

Complement detection in kidney biopsies – utility and challe... : Current Opinion in Nephrology
and Hypertension Complement detection in kidney biopsies – utility and challenges : Current …

Uncontrolled alternative pathway activation is the primary driver of several diseases, and it
contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor …

Background Data on therapy and outcome of dense deposit disease (DDD), C3
glomerulonephritis (C3GN), and immune-complex MPGN (IC-MPGN) in children are limited …