Switchable divergent asymmetric synthesis via organocatalysis

G Zhan, W Du, YC Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
The development of switchable chemo-, regio-, or diastereodivergent reactions, in which two
or more structurally and stereogenically different types of chiral products could be produced …

Control of Selectivity in Homogeneous Catalysis through Noncovalent Interactions

KT Mahmudov, AJL Pombeiro - Chemistry–A European …, 2023 - Wiley Online Library
Abstract The regio‐, site‐, stereo‐or chemoselective homogeneous catalytic transformations
are extremely important for the growth/success of the current chemical industry. Based on …

Electrochemical-induced benzyl C–H amination towards the synthesis of isoindolinones via aroyloxy radical-mediated C–H activation

M Yu, Y Gao, L Zhang, Y Zhang, Y Zhang, H Yi… - Green …, 2022 - pubs.rsc.org
The rapid synthesis of valuable isoindolinones with cheap and easily available starting
materials under mild conditions is of great importance, but is challenging. We enclose here a …

Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3+ 2] Cycloaddition

RA Unhale, MM Sadhu, VK Singh - Organic Letters, 2022 - ACS Publications
A novel organocatalytic asymmetric formal [3+ 2] cycloaddition of 3-substituted 1H-indoles
with in situ generated 3-hydroxy-isoindolinone-derived β, γ-alkynyl-α-ketimines has been …

Traceless Directing Group Assisted Cobalt‐Catalyzed C− H Carbonylation of Benzylamines

F Ling, C Ai, Y Lv, W Zhong - Advanced Synthesis & Catalysis, 2017 - Wiley Online Library
The first example of cobalt‐catalyzed C (sp2)− H carbonylation of benzylamines using a
traceless directing group is reported, which was successfully applied to the synthesis of N …

Chiral primary amine catalysis for asymmetric Mannich reactions of aldehydes with ketimines: stereoselectivity and reactivity

J Dai, D Xiong, T Yuan, J Liu, T Chen… - Angewandte Chemie …, 2017 - Wiley Online Library
The application potential of primary amine catalysts in the context of Mannich reactions of
aldehydes with ketimines is exemplified by isatin‐derived ketimines and cyclic …

Catalytic asymmetric synthesis of isoindolinones

W Gao, M Chen, Q Ding, Y Peng - Chemistry–An Asian Journal, 2019 - Wiley Online Library
As important reactive species, isoindolinones represent a cluster of valuable building blocks
for the construction of natural‐product‐like compounds. In particular, chiral isoindolinones …

Catalytic enantioselective synthesis of Mariline A and related isoindolinones through a biomimetic approach

C Min, Y Lin, D Seidel - Angewandte Chemie International …, 2017 - Wiley Online Library
The catalytic enantioselective synthesis of isoindolinones was achieved through the
condensation of 2‐acyl‐benzaldehydes and anilines. In the presence of 1 mol% of a chiral …

Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams

EM de Marigorta, JM de Los Santos… - Beilstein journal of …, 2019 - beilstein-journals.org
Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the
structure of many pharmaceutically active molecules. They can be often synthesized by …

[HTML][HTML] Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones

A Di Mola, M Tiffner, F Scorzelli… - Beilstein journal of …, 2015 - beilstein-journals.org
New bifunctional chiral ammonium salts were investigated in an asymmetric cascade
synthesis of a key building block for a variety of biologically relevant isoindolinones. With …