Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

The inherited marrow failure syndromes are a diverse set of genetic disorders characterized
by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly …

WHIM syndrome is an immunodeficiency disease characterized by neutropenia,
hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Abstract The Wiskott–Aldrich syndrome protein (WASP) is an important regulator of the actin
cytoskeleton that is required for many haematopoietic and immune cell functions, including …

The purpose of this Practice Parameter for the Diagnosis and Management of Primary
Immunodeficiency is to provide the consultant allergist/immunologist with a practical guide …

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne, OMIM#
604416) and familial recurrent arthritis (FRA) are rare inherited disorders of early onset …

The genetic dissection of various human infectious diseases has led to the definition of
inborn errors of human STAT1 immunity of four types, including (i) autosomal recessive (AR) …