Regulation of PCSK9 expression and function: mechanisms and therapeutic implications
X Xia, Z Peng, H Gu, M Wang, G Wang… - Frontiers in …, 2021 - frontiersin.org
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of low-density
lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL …
lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL …
The link between miRNAs and PCKS9 in atherosclerosis
MT Macvanin, ZM Gluvic, AN Klisic… - Current Medicinal …, 2024 - benthamdirect.com
Cardiovascular disease (CDV) represents the major cause of death globally.
Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder …
Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder …
Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing
JB Borges, VF Oliveira, C Dagli-Hernandez… - Gene, 2023 - Elsevier
Familial hypercholesterolemia (FH) is a monogenic disease characterized by high plasma
low-density lipoprotein cholesterol (LDL-c) levels and increased risk of premature …
low-density lipoprotein cholesterol (LDL-c) levels and increased risk of premature …
LDLR and PCSK9 3´UTR variants and their putative effects on microRNA molecular interactions in familial hypercholesterolemia: a computational approach
RCC de Freitas, RH Bortolin, JB Borges… - Molecular Biology …, 2023 - Springer
Background Familial hypercholesterolemia (FH) is caused by pathogenic variants in low-
density lipoprotein (LDL) receptor (LDLR) or its associated genes, including apolipoprotein …
density lipoprotein (LDL) receptor (LDLR) or its associated genes, including apolipoprotein …
Functional Analysis of 3′UTR Variants at the LDLR and PCSK9 Genes in Patients with Familial Hypercholesterolemia
J Sanguino Otero, C Rodríguez-Jiménez… - Human …, 2024 - Wiley Online Library
Familial hypercholesterolemia (FH) is an autosomal dominant disease with an estimated
prevalence of 1 in 200‐250 individuals. Patients with FH are at increased risk of premature …
prevalence of 1 in 200‐250 individuals. Patients with FH are at increased risk of premature …
miR-423-5p Regulates Skeletal Muscle Growth and Development by Negatively Inhibiting Target Gene SRF
Y Pang, J Liang, J Huang, G Lan, F Chen, H Ji, Y Zhao - Genes, 2024 - mdpi.com
The process of muscle growth directly affects the yield and quality of pork food products.
Muscle fibers are created during the embryonic stage, grow following birth, and regenerate …
Muscle fibers are created during the embryonic stage, grow following birth, and regenerate …
Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial hypercholesterolemia
A Cerda, RH Bortolin, MY Yoshinaga… - Chemistry and Physics …, 2023 - Elsevier
Familial hypercholesterolemia (FH) is a disorder of lipid metabolism that causes elevated
low-density lipoprotein cholesterol (LDL-c) and increased premature atherosclerosis risk …
low-density lipoprotein cholesterol (LDL-c) and increased premature atherosclerosis risk …
Prognostic Values and Prospective Pathway Signaling of miR-25 in Non-Small Cell Lung Cancer: A Bioinformatics Analysis Based on Gene Expression Omnibus
Y Liu, Y Wei, H Liang, D Li, K Chen… - Science of Advanced …, 2023 - ingentaconnect.com
MicroRNAs (MiRNAs) are believed to significantly influence the occurrence and
development of Non-small cell lung cancer (NSCLC). This study aims to clarify the action of …
development of Non-small cell lung cancer (NSCLC). This study aims to clarify the action of …