Evaluation of the TCR repertoire as a predictive and prognostic biomarker in cancer: diversity or clonality?

A Aran, L Garrigós, G Curigliano, J Cortés, M Martí - Cancers, 2022 - mdpi.com
Simple Summary The TCR is the T cell antigen receptor, and it is responsible of the T cell
activation, through the HLA-antigen complex recognition. Studying the TCR repertoire in …

Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours

Q Geng, X Cao, D Fan, Q Wang, X Wang… - British Journal of …, 2023 - Wiley Online Library
Autoimmune diseases (ADs) are closely related to malignant tumours. On the one hand,
ADs can increase the incidence of tumours; on the other hand, malignant tumours can cause …

Nanovaccine displaying immunodominant T cell epitopes of fibroblast activation protein is effective against desmoplastic tumors

H Shin, Y Kim, S Jon - ACS nano, 2023 - ACS Publications
Cancer-associated fibroblasts (CAFs), which are dominant cell types in the tumor
microenvironment (TME), support tumor growth by secreting cytokines and forming an …

SARS-CoV-2 infection triggers auto-immune response in ARDS

P Juanes-Velasco, A Landeira-Viñuela… - Frontiers in …, 2022 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of
the major complications in COVID-19 patients. Dysregulation of the immune system and …

Association of elevated autoantibody to high expression of GNAS in hepatocellular carcinoma

K Wang, C Qiu, M Xing, M Li, B Wang, H Ye, J Shi… - Heliyon, 2023 - cell.com
Purpose This study was based on hepatocellular carcinoma (HCC) patients of early-stage to
explore the diagnostic capability and possible production causes of anti-GNAS …

Bioinformatics analysis of the pathogenic link between Epstein-Barr virus infection, systemic lupus erythematosus and diffuse large B cell lymphoma

QY Zhu - Scientific Reports, 2023 - nature.com
Epstein-Barr virus (EBV) is a risk factor for diffuse large B-cell lymphoma (DLBCL) and
systemic lupus erythematosus (SLE). While prior research has suggested a potential …

Extracellular vesicle autoantibodies

Y Hua, P Jiang, C Dai, M Li - Journal of Autoimmunity, 2024 - Elsevier
Autoantibodies are immunoglobulin proteins produced by autoreactive B cells responding to
self-antigens. Extracellular vesicles (EVs) are membranous structures released by almost all …

State-Of-The-Art Advancements on Cancer Vaccines and Biomarkers

S Strum, MH Andersen, IM Svane, LL Siu… - American Society of …, 2024 - ascopubs.org
The origins of cancer vaccines date back to the 1800s. Since then, there have been
significant efforts to generate vaccines against solid and hematologic malignancies using a …

Effective combination immunotherapy with oncolytic adenovirus and anti-PD-1 for treatment of human and murine ovarian cancers

C Heiniö, J Clubb, T Kudling, D Quixabeira… - Diseases, 2022 - mdpi.com
Simple Summary This study was conducted to find a new, more efficient, treatment for
ovarian cancer. A combination of an oncolytic adenovirus (TILT-123) with immune …

Systematic evaluation of plasma signaling cascades by functional proteomics approaches: SARS‐CoV‐2 infection as model

P Juanes‐Velasco, ML García‐Vaquero… - PROTEOMICS …, 2022 - Wiley Online Library
Abstract Purpose Acute phase reactants (APRs) play a critical role in inflammation. The
difference in their physiological functions or the different dynamic ranges of these proteins in …