Head and neck carcinoma (HNC) are diseases arising from several tracts of the
aerodigestive ways. Most HNC are squamous cell carcinoma (SCCHN). Immunotherapy is a …

Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …

Evolution of tumor cell phenotypes promotes heterogeneity and therapy resistance. Here we
found that induction of CD73, the enzyme that generates immunosuppressive adenosine, is …

Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine
regulation and paracrine communication. By performing live calcium imaging experiments …

Among the various biological properties presented by Mesenchymal Stem Cells (MSCs),
their ability to control the immune response and fight pathogen infection through the …

Systemic sclerosis (SSc) is an intractable autoimmune disease with unmet medical needs.
Conventional immunosuppressive therapies have modest efficacy and obvious side effects …

Adipose tissue is recognized as an important organ with metabolic, regulatory, and plastic
roles. Adipose tissue-derived stem cells (ASCs) with self-renewal properties localize in the …

Abstract Mesenchymal Stem Cells (MSCs) have gained prominence as an important tool in
cell therapy, especially considering their capacity to control the immune system. Due to this …

COVID-19 is a disease characterized by a strong inflammatory response in severe cases,
which fails to respond to corticosteroid therapy. In the context of the current COVID-19 …

Mesenchymal stem cell (MSC) therapy represents a promising approach for the treatment of
osteoarthritis (OA). MSCs can be readily isolated from multiple sources and expanded ex …