microRNAs in action: biogenesis, function and regulation

R Shang, S Lee, G Senavirathne, EC Lai - Nature Reviews Genetics, 2023 - nature.com
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

[HTML][HTML] MicroRNAs: target recognition and regulatory functions

DP Bartel - cell, 2009 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 23 nt RNAs that play important gene-regulatory
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …

MicroRNA Targets in Drosophila

A Enright, B John, U Gaul, T Tuschl, C Sander, D Marks - Genome biology, 2003 - Springer
The recent discoveries of microRNAs (miRNAs) and characterization of the first few targets
of their gene products in Caenorhabditis elegans and Drosophila melanogaster have set the …

MicroRNA control of signal transduction

M Inui, G Martello, S Piccolo - Nature reviews Molecular cell biology, 2010 - nature.com
MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene
expression. After the identification of hundreds of miRNAs, the challenge is now to …

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

EC Lai - Nature genetics, 2002 - nature.com
Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are
generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly …

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

YS Lee, K Nakahara, JW Pham, K Kim, Z He… - Cell, 2004 - cell.com
Abstract The RNase III enzyme Dicer processes RNA into siRNAs and miRNAs, which direct
a RNA-induced silencing complex (RISC) to cleave mRNA or block its translation (RNAi) …

MicroRNA functions in animal development and human disease

I Alvarez-Garcia, EA Miska - 2005 - journals.biologists.com
Five years into thesmall RNA revolution'it is hard not to share in the excitement about the
rapidly unravelling biology of microRNAs. Since the discovery of the first microRNA gene, lin …

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants

JS Yang, EC Lai - Molecular cell, 2011 - cell.com
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

MJ Axtell, JO Westholm, EC Lai - Genome biology, 2011 - Springer
Vive la différence: biogenesis and evolution of microRNAs in plants and animals | Genome
Biology Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

S Bagga, J Bracht, S Hunter, K Massirer, J Holtz… - Cell, 2005 - cell.com
MicroRNAs (miRNAs) are∼ 22 nucleotide RNAs that negatively regulate the expression of
protein-coding genes. In a present model of miRNA function in animals, miRNAs that form …