Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been
attributed to a combination of genetic, environmental and metabolic factors. Chronic …

In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3
(NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in …

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract, which has been shown to increase the incidence of colorectal cancer. Recent studies …

Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-
induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA) …

Terpenes are one of the most abundant classes of secondary metabolites produced by
plants and can be divided based on the number of isoprene units (C5) in monoterpenes (2 …

Background Pancreatic cancer is one of the most serious and lethal human cancers with a
snowballing incidence around the world. The natural product celastrol has also been widely …

Background The incidence and prevalence of gout have been steadily increasing globally,
which has resulted in gout research attracting consistently increased attention. This study …

Background: One of the most common microvascular complications of diabetes is diabetic
kidney disease (DKD). The Huajuxiaoji formula (HJXJ) has shown clinical efficacy for DKD; …

Abstract Ethnopharmacological relevance Daphnes Cortex (Daphne Giraldii Nitsche, DGN)
is a popular traditional Chinese herbal medicine for traumatic injuries and rheumatoid …