[HTML][HTML] Profiling the antimalarial mechanism of artemisinin by identifying crucial target proteins
P Gao, J Wang, J Chen, L Gu, C Wang, L Xu, YK Wong… - Engineering, 2023 - Elsevier
The widespread use of artemisinin (ART) and its derivatives has significantly reduced the
global burden of malaria; however, malaria still poses a serious threat to global health …
global burden of malaria; however, malaria still poses a serious threat to global health …
β-Carboline derivatives tackling malaria: biological evaluation and docking analysis
Increasing resistance to presently available antimalarial drugs urges the need to look for
new promising compounds. The β-carboline moiety, present in several biologically active …
new promising compounds. The β-carboline moiety, present in several biologically active …
Discovery of dual-target natural antimalarial agents against DHODH and PMT of Plasmodium falciparum: pharmacophore modelling, molecular docking, quantum …
EM Elamin, SE Eshage, SM Mohmmode… - SAR and QSAR in …, 2023 - Taylor & Francis
Malaria is a lethal disease that claims thousands of lives worldwide annually. The objective
of this study was to identify new natural compounds that can target two P. falciparum …
of this study was to identify new natural compounds that can target two P. falciparum …
In silico analysis of soybean phytocompounds against Plasmodium falciparum
Introduction Natural products have been indispensable since immemorial and still act as a
supportive healer. Parasitic diseases are a significant hurdle for humans and are …
supportive healer. Parasitic diseases are a significant hurdle for humans and are …
Quantitative Structure Activity Relationship (QSAR) investigations and molecular docking analysis of plasmodium protein farnesyltransferase inhibitors as potent …
The development of farnesyltransferase inhibitors based on the benzophenone scaffold
directed against Plasmodium falciparum is considered a strategy in malaria treatment. In this …
directed against Plasmodium falciparum is considered a strategy in malaria treatment. In this …
Computational and experimental elucidation of Plasmodium falciparum phosphoethanolamine methyltransferase inhibitors: Pivotal drug target
Introduction Plasmodium falciparum synthesizes phosphatidylcholine for the membrane
development through serine decarboxylase–phosphoethanolamine methyltransferase …
development through serine decarboxylase–phosphoethanolamine methyltransferase …
Antimalarial activity of Curcuma caesia against 3D7 and K1 strains of Plasmodium falciparum
Background: Malaria is one of the severe tropical disease and majority of deaths occurred
due to Plasmodium falciparum. Lack of a vaccine and the widespread resistance to …
due to Plasmodium falciparum. Lack of a vaccine and the widespread resistance to …
Development of selective Inhibitors of crucial drug target Phosphoethanolamine methyltransferase of Plasmodium falciparum based on Chemo informatics and in vitro …
The chemo informatics and simulation approaches are highly preferred to develop drug
candidate, applied in the study to develop a combinatorial library to meet, the need of new …
candidate, applied in the study to develop a combinatorial library to meet, the need of new …