Significance: Maintenance of mitochondrial quality is essential for cellular homeostasis.
Among processes responsible for preserving healthy mitochondria, mitophagy selectively …

Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and
metastasis. Therefore, clarification of the mechanisms involved in CSC stemness …

Background: Lung cancer is the leading cause of cancer-related death worldwide, of which
lung adenocarcinoma (LUAD) is one of the main histological subtypes. Mitochondria are …

Mitochondria are key regulators of cell survival and are involved in a plethora of
mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) …

Evidence shows that there is a synergistic, bidirectional association between cancer and
aging with many shared traits. Age itself is a risk factor for the onset of most cancers, while …

Simple Summary Cancer cells display among its hallmark genomic instability. This is a
progressive tendency in accumulate genome alteration which contributes to the damage of …

Mitochondria are physically associated with other organelles, such as ER and lysosomes,
forming a complex network that is crucial for cell homeostasis regulation. Inter-organelle …

Cellular therapy exerts profound therapeutic potential for curing a broad spectrum of
diseases. Adult stem cells reside within a specified dynamic niche in vivo, which is essential …

As mitochondria network together to act as the master sensors and effectors of apoptosis,
ATP production, reactive oxygen species management, mitophagy/autophagy, and …

Autophagy regenerates cellular nutrients, recycles metabolites, and maintains hemostasis
through multistep signaling pathways, in conjunction with lysosomal degradation …