Scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) are
prion diseases in ruminants with considerable impact on animal health and welfare. They …

Classical scrapie has proved to be a notoriously difficult disease to control due to a poor
understanding of its natural history. The recognition of disease risk linkage to PrP genotype …

Scrapie in small ruminants belongs to transmissible spongiform encephalopathies (TSEs),
or prion diseases, a family of fatal neurodegenerative disorders that affect humans and …

This introduction provides a telegraphic overview of the processes of zoonotic viral
emergence, the intricacies of host–virus interactions, and the distinct role of biological …

The aim of this study was to analyze the epidemiology and prion protein (PrP) genetics in
scrapie-affected sheep flocks in Germany. For this purpose, 224 German scrapie cases in …

Great Britain and elsewhere have detected atypical scrapie infection in sheep with PrP
genotypes thought to be genetically resistant to the classical form of scrapie. DNA …

In sheep, susceptibility to scrapie is mainly influenced by polymorphisms of the PrP gene. In
goats, there are to date few data related to scrapie susceptibility association with PrP gene …

Isolates of atypical scrapie recently identified in sheep and goats in France were compared
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …

In goats, several field studies have identified coding mutations of the gene encoding the
prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a …

Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases
characterized by the aggregation and accumulation of the misfolded prion protein in the …