Chalcone: a privileged structure in medicinal chemistry

C Zhuang, W Zhang, C Sheng, W Zhang, C Xing… - Chemical …, 2017 - ACS Publications
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Microwave‐assisted synthesis and evaluation of antimicrobial activity of 3‐{3‐(s‐aryl and s‐heteroaromatic)acryloyl}‐2H‐chromen‐2‐one derivatives

OO Ajani, OC Nwinyi - Journal of Heterocyclic Chemistry, 2010 - Wiley Online Library
The exploration of potential utilization of microwaves as an energy source for heterocyclic
synthesis was herein investigated using condensation of 3‐acetylcoumarin (1) with aromatic …

Diverse benzothiazole based chemodosimeters for the detection of cyanide in aqueous media and in HeLa cells

B Vidya, M Iniya, G Sivaraman, RV Sumesh - Sensors and Actuators B …, 2017 - Elsevier
Benzothiazole derivatives bearing anthracenyl, pyrenyl and N, N,-dimethylaminophenyl as
an efficient chemodosimeter for cyanide ions are designed and synthesized. The …

Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe

SC Lee, NY Kang, SJ Park, SW Yun… - Chemical …, 2012 - pubs.rsc.org
We report the first fluorescent diamino-chalcone library and its application in the discovery of
a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe …

Photophysical study and biological applications of synthetic chalcone-based fluorescent dyes

S Wangngae, K Chansaenpak, J Nootem, U Ngivprom… - Molecules, 2021 - mdpi.com
A chalcone series (3a–f) with electron push–pull effect was synthesized via a one-pot
Claisen–Schmidt reaction with a simple purification step. The compounds exhibited strong …

Solvent polarity dependent excited state dynamics of 2′-hydroxychalcone derivatives

H Song, Z Kuang, X Wang, Y Guo, Q Guo… - The Journal of …, 2018 - ACS Publications
The excited-state properties of 4-(dimethylamino) methoxychalcones (DEAMC) and its
derivative 4-(dimethylamino) hydroxychalcones (DEAHC) were investigated in various …

Characterization of the fluorescence properties of 4‐dialkylaminochalcones and investigation of the cytotoxic mechanism of chalcones

B Zhou, P Jiang, J Lu, C Xing - Archiv der Pharmazie, 2016 - Wiley Online Library
Understanding the mechanisms responsible for the various biological activities of
chalcones, particularly the direct cellular targets, presents an unmet challenge. Here, we …

New insight into the origin of the red/near-infrared intense fluorescence of a crystalline 2-hydroxychalcone derivative: a comprehensive picture from the excited-state …

NI Zahid, MS Mahmood, B Subramanian… - The Journal of …, 2017 - ACS Publications
Fluorescence upconversion and transient absorption techniques are used to explain the
source of the intense red/near-infrared emission of crystalline 4-dimethylamino-2 …

Privileged chalcone scaffolds in drug discovery

L Ding, J Yan, T Li, Z Miao, H Liu, C Zhuang - Privileged Scaffolds in Drug …, 2023 - Elsevier
Chalcones are typically privileged scaffolds found in many naturally occurring compounds.
They are widely used as lead compounds for designing novel bioactive molecules with a …

Green synthesis, antibacterial activity and computational study of pyrazoline and pyrimidine derivatives from 3-(3, 4-dimethoxy-phenyl-1-(2, 5-dimethyl-thiophen-3-yl) …

SA Khan, AM Asiri, S Kumar, K Sharma - European Journal of …, 2014 - eurjchem.com
Various pyrazoline and pyrimidine derivatives were synthesized by the reaction of
thiosemicarbazide/phenyl hydrazine/hydrazine hydtate/thiourea/urea with 3-(3, 4-dimethoxy …