Design, optimization, production and activity testing of recombinant immunotoxins expressed in plants and plant cells for the treatment of monocytic leukemia

M Knödler, K Frank, L Kerpen, JF Buyel - Bioengineered, 2023 - Taylor & Francis
Antibody–drug conjugates (ADCs) can improve therapeutic indices compared to plain
monoclonal antibodies (mAbs). However, ADC synthesis is complex because the …

Preparation of a novel EGFR specific immunotoxin and its efficacy of anti-colorectal cancer in vitro and in vivo

S Wu, C Deng, C Zhang, J Xiong, X Gu, Z Wang… - Clinical and …, 2021 - Springer
Objectives Epithelial growth factor receptor (EGFR), as a malignancy marker, is overly
expressed in multiple solid tumors including colorectal neoplasms, one of the most prevalent …

Development and plant-based expression of recombinant immunotoxins for the targeted treatment of myelomonocytic leukemia

M Knödler, JF Buyel, LM Blank - 2023 - publications.rwth-aachen.de
Immunotoxine sind hochwirksame, biopharmazeutische Krebsmedikamente, die aus einem
Antikörper und einem Wirkstoff bestehen und die therapeutische Wirksamkeit im Vergleich …

[HTML][HTML] Enhanced production of recombinant HALT-1 pore-forming toxin using two-step chromatographic procedure

WY Yap, LW Loo, HX Sha, JS Hwang - MethodsX, 2023 - Elsevier
Abstract Hydra actinoporin-like toxin-1 (HALT-1) has been isolated from Hydra
magnipapillata and is highly cytolytic against various human cells including erythrocyte …

[PDF][PDF] Coelenterate toxins, its pharmaceutical and therapeutic effects

S SHARMA, RK UPADHYAY - Int J Curr Pharm Res, 2021 - academia.edu
Present review article emphasizes species specific coelenterate toxins, its pharmaceutical
and therapeutic effects. Most of the coelenterates inflict venom accidently by using …