Structural and functional diversity of type IV secretion systems

TRD Costa, JB Patkowski, K Macé, PJ Christie… - Nature Reviews …, 2024 - nature.com
Considerable progress has been made in recent years in the structural and molecular
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …

Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …

Cryo-EM structure of a type IV secretion system

K Macé, AK Vadakkepat, A Redzej, N Lukoyanova… - Nature, 2022 - nature.com
Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

TRD Costa, C Felisberto-Rodrigues, A Meir… - Nature Reviews …, 2015 - nature.com
Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

[HTML][HTML] Agrobacterium-mediated plant transformation: biology and applications

HH Hwang, M Yu, EM Lai - The arabidopsis book, 2017 - ncbi.nlm.nih.gov
Plant genetic transformation heavily relies on the bacterial pathogen Agrobacterium
tumefaciens as a powerful tool to deliver genes of interest into a host plant. Inside the plant …

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

NR Salama, ML Hartung, A Müller - Nature Reviews Microbiology, 2013 - nature.com
The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes
approximately 50% of the human population, but only causes overt gastric disease in a …

Molecular architecture of bacterial type IV secretion systems

MJ Sheedlo, MD Ohi, DB Lacy, TL Cover - PLoS pathogens, 2022 - journals.plos.org
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can
horizontally transfer DNA through conjugation and deliver effector proteins into a wide range …

Protein-injection machines in bacteria

JE Galán, G Waksman - Cell, 2018 - cell.com
Many bacteria have evolved specialized nanomachines with the remarkable ability to inject
multiple bacterially encoded effector proteins into eukaryotic or prokaryotic cells. Known as …

A comprehensive guide to pilus biogenesis in Gram-negative bacteria

MK Hospenthal, TRD Costa, G Waksman - Nature reviews microbiology, 2017 - nature.com
Pili are crucial virulence factors for many Gram-negative pathogens. These surface
structures provide bacteria with a link to their external environments by enabling them to …