Principles of nanoparticle delivery to solid tumors

WCW Chan - BME frontiers, 2023 - spj.science.org
The effective treatment of patients with cancer hinges on the delivery of therapeutics to a
tumor site. Nanoparticles provide an essential transport system. We present 5 principles to …

[HTML][HTML] Preparation and application of calcium phosphate nanocarriers in drug delivery

C Qiu, Y Wu, Q Guo, Q Shi, J Zhang, Y Meng, F Xia… - Materials Today Bio, 2022 - Elsevier
Calcium phosphate nanoparticles represent promising materials for drug delivery because
of its favorable properties, including biocompatibility, biodegradability and strong affinity for …

[HTML][HTML] An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice

WC Chou, Q Chen, L Yuan, YH Cheng, C He… - Journal of Controlled …, 2023 - Elsevier
The critical barrier for clinical translation of cancer nanomedicine stems from the inefficient
delivery of nanoparticles (NPs) to target solid tumors. Rapid growth of computational power …

Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Z Sang, L Xu, R Ding, M Wang, X Yang, X Li… - Nature …, 2023 - nature.com
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …

Non‐Pore Dependent and MMP‐9 Responsive Gelatin/Silk Fibroin Composite Microparticles as Universal Delivery Platform for Inhaled Treatment of Lung Cancer

S Gou, G Wang, Y Zou, W Geng, T He, Z Qin… - Advanced …, 2023 - Wiley Online Library
Developing a drug delivery platform that possesses universal drug loading capacity to meet
various requirements of cancer treatment is a challenging yet interesting task. Herein, a self …

Rational nanoparticle design: Optimization using insights from experiments and mathematical models

O Richfield, AS Piotrowski-Daspit, K Shin… - Journal of Controlled …, 2023 - Elsevier
Polymeric nanoparticles are highly tunable drug delivery systems that show promise in
targeting therapeutics to specific sites within the body. Rational nanoparticle design can …

Radiotherapy potentiates the P-selectin targeted cancer drug delivery based on a cisplatin and mitoxantrone coassembled fucoidan nanogel

H Wang, H Deng, M Gao, Y Zhang, R Liu… - ACS Materials …, 2023 - ACS Publications
Targeted delivery of coencapsulated drugs can increase therapeutic indices of cancers
including improved tumor inhibition and safety profile. However, most cancers lack tumor …

Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers

C Moloney, F Mehradnia, RJ Cavanagh… - Biomaterials …, 2023 - pubs.rsc.org
The therapeutic efficacy of nanomedicines is highly dependent on their access to target sites
in the body, and this in turn is markedly affected by their size, shape and transport properties …

Advanced nanomedicines for the treatment of age-related macular degeneration

YS Kwon, Z Han - Nanoscale, 2024 - pubs.rsc.org
The critical and unmet medical need for novel therapeutic advancements in the treatment of
age-related macular degeneration (AMD) cannot be overstated, particularly given the aging …

[HTML][HTML] Lipid-based nanoparticles as drug delivery carriers for cancer therapy

I Waheed, A Ali, H Tabassum, N Khatoon… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Cancer is a severe disease that results in death in all countries of the world. A nano-based
drug delivery approach is the best alternative, directly targeting cancer tumor cells with …