Walking exercise is the most effective noninvasive therapy that improves walking ability in
peripheral artery disease (PAD). Biologic mechanisms by which exercise improves walking …

Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities, which
leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest …

Chronic kidney disease (CKD) leads to increased skeletal muscle fatigue, weakness, and
atrophy. Previous work has implicated mitochondria within the skeletal muscle as a mediator …

The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia
(CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a …

The natural polyphenols mangiferin and luteolin have free radical-scavenging properties,
induce the antioxidant gene program and down-regulate the expression of superoxide …

Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet
therapeutic development has remained stagnant. Skeletal muscle health and function has …

Chronic kidney disease (CKD) is a strong risk factor for peripheral artery disease (PAD) that
is associated with worsened clinical outcomes. CKD leads to the accumulation of tryptophan …

Background: Critical limb ischemia is a manifestation of peripheral artery disease that
carries significant mortality and morbidity risk in humans, although its genetic determinants …

Background Loss of mitochondrial function contributes to fatigue, exercise intolerance and
muscle weakness, and is a key factor in the disability that develops with age and a wide …

Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease,
especially in patients with the most severe clinical manifestation—critical limb ischemia …