Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review

G Yadav, S Ganguly - European journal of medicinal chemistry, 2015 - Elsevier
Benzimidazoles are the fused heterocyclic ring systems which form an integral part of
vitamin B 12 and have been luring many researchers all over the world to assess their …

Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Anticancer copper pyridine benzimidazole complexes: ROS generation, biomolecule interactions, and cytotoxicity

KE Prosser, SW Chang, F Saraci, PH Le… - Journal of inorganic …, 2017 - Elsevier
Abstract The Cu (II) complex CuCl 2 (pbzH), pbzH= 2-(2-pyridyl) benzimidazole, and
derivatives modified at the non-coordinated nitrogen of the benzimidazole fragment, have …

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

M Patel, G Avashthi, A Gacem, MS Alqahtani, HK Park… - Molecules, 2023 - mdpi.com
Heterocyclic compounds are significant lead drug candidates based on their various
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …

Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium (II), rhodium (III) and iridium (III) complexes of 2-phenylbenzimidazoles

L Rylands, A Welsh, K Maepa, T Stringer… - European Journal of …, 2019 - Elsevier
Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial
activity against Plasmodium falciparum and are widely used as scaffolds for metal-based …

Plasmepsin inhibitors in antimalarial drug discovery: medicinal chemistry and target validation (2000 to present)

PM Cheuka, G Dziwornu, J Okombo… - Journal of medicinal …, 2020 - ACS Publications
Plasmepsins represent novel antimalarial drug targets. However, plasmepsin-based
antimalarial drug discovery efforts in the past 2 decades have generally suffered some …

Computer-aided drug discovery approaches against the tropical infectious diseases malaria, tuberculosis, trypanosomiasis, and leishmaniasis

PM Njogu, EM Guantai, E Pavadai… - ACS infectious …, 2016 - ACS Publications
Despite the tremendous improvement in overall global health heralded by the adoption of
the Millennium Declaration in the year 2000, tropical infections remain a major health …

[HTML][HTML] On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

RL Carvalho, AS de Miranda… - Beilstein Journal of …, 2021 - beilstein-journals.org
Several valuable biologically active molecules can be obtained through C–H activation
processes. However, the use of expensive and not readily accessible catalysts complicates …