CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
LTP induction by structural rather than enzymatic functions of CaMKII
JE Tullis, ME Larsen, NL Rumian, RK Freund… - Nature, 2023 - nature.com
Learning and memory are thought to require hippocampal long-term potentiation (LTP), and
one of the few central dogmas of molecular neuroscience that has stood undisputed for …
one of the few central dogmas of molecular neuroscience that has stood undisputed for …
Fast and deep phosphoproteome analysis with the Orbitrap Astral mass spectrometer
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles
in myriad cell processes. That said, detecting and quantifying protein phosphorylation has …
in myriad cell processes. That said, detecting and quantifying protein phosphorylation has …
CaMKII holoenzyme mechanisms that govern the LTP versus LTD decision
SG Cook, OR Buonarati, SJ Coultrap, KU Bayer - Science Advances, 2021 - science.org
Higher brain functions are thought to require synaptic frequency decoding that can lead to
long-term potentiation (LTP) or depression (LTD). We show that the LTP versus LTD …
long-term potentiation (LTP) or depression (LTD). We show that the LTP versus LTD …
Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep
The reduced sleep duration previously observed in Camk2b knockout mice revealed a role
for Ca2+/calmodulin-dependent protein kinase II (CaMKII) β as a sleep-promoting kinase …
for Ca2+/calmodulin-dependent protein kinase II (CaMKII) β as a sleep-promoting kinase …
Role of CAMK2D in neurodevelopment and associated conditions
PMF Rigter, C de Konink, MJ Dunn, MP Onori… - The American Journal of …, 2024 - cell.com
The calcium/calmodulin-dependent protein kinase type 2 (CAMK2) family consists of four
different isozymes, encoded by four different genes—CAMK2A, CAMK2B, CAMK2G, and …
different isozymes, encoded by four different genes—CAMK2A, CAMK2B, CAMK2G, and …
Spatiotemporal patterns of gene expression around implanted silicon electrode arrays
CH Thompson, A Saxena, N Heelan… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Intracortical brain interfaces are an ever evolving technology with growing
potential for clinical and research applications. The chronic tissue response to these devices …
potential for clinical and research applications. The chronic tissue response to these devices …
Camkiiβ in neuronal development and plasticity: An emerging candidate in brain diseases
The calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous and central
player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α …
player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α …
Dynamic characterization of structural, molecular, and electrophysiological phenotypes of human-induced pluripotent stem cell-derived cerebral organoids, and …
Background: The development of 3D cerebral organoid technology using human-induced
pluripotent stem cells (iPSCs) provides a promising platform to study how brain diseases are …
pluripotent stem cells (iPSCs) provides a promising platform to study how brain diseases are …