Cardiac hypertrophy is promoted by adrenergic over-activation and represents an
independent risk factor for cardiovascular morbidity and mortality. The basic knowledge …

The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist
administration represent an experimental approach of persisting interest. These models …

Cardiac β-adrenergic overstimulation results in oxidative stress, hypertrophy, ischemia,
lesion, and fibrosis rendering the heart vulnerable to malignant arrhythmias. We aimed to …

Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis.
Oxidative stress, endoplasmic reticulum (ER) stress, and canonical Smad3 pathway are …

On the one hand, sustained β-adrenergic stress is a hallmark of heart failure (HF) and exerts
maladaptive cardiac remodelling. On the other hand, acute β-adrenergic stimulation …

Hypothesis The role of non-cardiomyocytes in cardiac remodeling and fibrosis has not been
totally understood until now. This study investigated if endothelial cell (EC)-specific calpain …

En 31 de diciembre del 2019 la Organización Mundial de la Salud fue informada por las
autoridades sanitarias chinas de la aparición de casos de neumonía de origen desconocido …

Nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) is involved in fibrosis of
multiple organs, such as kidney, liver, lung, and the like. However, the role of NLRP3 in …

The present study was undertaken to determine tonin expression and activity in rat heart
presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme …