Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

ABSTRACT Introduction Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis
are the causative agents of toxoplasmosis, trichomoniasis, and giardiasis, three important …

The control of coccidiosis, causing huge economic losses in the poultry industry, is facing
the stagnation of the development of new drugs and the emergence of drug resistance …

The human malaria parasite Plasmodium falciparum (P. falciparum) continues to pose a
significant public health challenge, leading to millions of fatalities globally. Halofuginone …

Photoreceptor cell death can cause progressive and irreversible visual impairments. Still,
effective therapies on retinal neuroprotection are not available. Hypoxia-inducible factors …

Glutamyl-prolyl-tRNA synthetase (EPRS1), an aminoacyl-tRNA synthetase (ARS) ligating
glutamic acid and proline to their corresponding tRNAs, plays an essential role in decoding …

Halofuginone (HFG) is a widely used anti-coccidiosis drug in animal husbandry. There is an
urgent need for a rapid detection method to detect HFG residues in chicken and beef to …

Heterocyclic compounds play an important role in the pharmaceutical industry, and one of
the most common structures used in their skeletons is piperidine building blocks. Thus, the …

This study evaluated the in vitro effectiveness of anti-cryptosporidial agents nitazoxanide,
halofuginone, the pyrazolopyridine analog KDU731, and paromomycin (PMC) in combating …

Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by chronic
inflammation and excessive proliferation of the synovium. Currently, treatment options focus …