This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-
induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag …

Hypertension is a primary risk factor for cardiovascular diseases including myocardial
infarction and stroke. Major determinants of blood pressure are vasodilatory factors such as …

The controlled regulation of nitric oxide (NO) synthesis in endothelial cells and
cardiomyocytes by the endothelial form of nitric oxide synthase (eNOS or NOS3) is essential …

Rather than being a constitutive enzyme as was first suggested, endothelial nitric oxide
synthase (eNOS) is dynamically regulated at the transcriptional, posttranscriptional, and …

Numerous aspects of vascular homeostasis are modulated by nitric oxide and reactive
oxygen species (ROS). The production of these is dramatically influenced by mechanical …

The application of fluid shear stress to endothelial cells elicits the formation of nitric oxide
(NO) and phosphorylation of the endothelial NO synthase (eNOS). Shear stress also elicits …

Endothelial nitric oxide synthase (eNOS) plays a central role in maintaining cardiovascular
homeostasis by controlling NO bioavailability. The activity of eNOS in vascular endothelial …

Formation of NO by endothelial NOS (eNOS) is a central process in the homeostatic
regulation of vascular functions including blood pressure regulation, and fluid shear stress …

The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control
mechanisms impinging on level and activity of the enzyme. This review aims at summarizing …