Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
ATM's role in the repair of DNA double-strand breaks
A Shibata, PA Jeggo - Genes, 2021 - mdpi.com
Ataxia telangiectasia mutated (ATM) is a central kinase that activates an extensive network
of responses to cellular stress via a signaling role. ATM is activated by DNA double strand …
of responses to cellular stress via a signaling role. ATM is activated by DNA double strand …
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
AC Howes, O Perisic, RL Williams - Science Advances, 2023 - science.org
Ataxia-telangiectasia mutated (ATM) is a master kinase regulating DNA damage response
that is activated by DNA double-strand breaks. However, ATM is also directly activated by …
that is activated by DNA double-strand breaks. However, ATM is also directly activated by …
ATM-deficient cancers provide new opportunities for precision oncology
NR Jette, M Kumar, S Radhamani, G Arthur, S Goutam… - Cancers, 2020 - mdpi.com
Poly-ADP ribose polymerase (PARP) inhibitors are currently used in the treatment of several
cancers carrying mutations in the breast and ovarian cancer susceptibility genes BRCA1 …
cancers carrying mutations in the breast and ovarian cancer susceptibility genes BRCA1 …
[HTML][HTML] Oxidative stress and the multifaceted roles of ATM in maintaining cellular redox homeostasis
JH Lee - Redox Biology, 2024 - Elsevier
The ataxia telangiectasia mutated (ATM) protein kinase is best known as a master regulator
of the DNA damage response. However, accumulating evidence has unveiled an equally …
of the DNA damage response. However, accumulating evidence has unveiled an equally …
Molecular basis of human ATM kinase inhibition
K Stakyte, M Rotheneder, K Lammens… - Nature structural & …, 2021 - nature.com
Human checkpoint kinase ataxia telangiectasia-mutated (ATM) plays a key role in initiation
of the DNA damage response following DNA double-strand breaks. ATM inhibition is a …
of the DNA damage response following DNA double-strand breaks. ATM inhibition is a …
Structure of the human ATM kinase and mechanism of Nbs1 binding
C Warren, NP Pavletich - Elife, 2022 - elifesciences.org
DNA double-strand breaks (DSBs) can lead to mutations, chromosomal rearrangements,
genome instability, and cancer. Central to the sensing of DSBs is the ATM (Ataxia …
genome instability, and cancer. Central to the sensing of DSBs is the ATM (Ataxia …
ATM: Functions of ATM kinase and its relevance to hereditary tumors
S Ueno, T Sudo, A Hirasawa - International journal of molecular sciences, 2022 - mdpi.com
Ataxia–telangiectasia mutated (ATM) functions as a key initiator and coordinator of DNA
damage and cellular stress responses. ATM signaling pathways contain many downstream …
damage and cellular stress responses. ATM signaling pathways contain many downstream …
Structure and function of the apical PIKKs in double-strand break repair
Members of the phosphatidylinositol 3ʹ kinase (PI3K)-related kinases (PIKKs) family,
including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), ataxia telangiectasia …
including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), ataxia telangiectasia …
Enzymology and dynamics by cryogenic electron microscopy
Cryogenic electron microscopy (cryo-EM) has revolutionized the field of structural biology,
particularly in solving the structures of large protein complexes or cellular machineries that …
particularly in solving the structures of large protein complexes or cellular machineries that …