[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Risk factors for progression of age‐related macular degeneration

TJ Heesterbeek, L Lorés‐Motta… - Ophthalmic and …, 2020 - Wiley Online Library
Purpose Age‐related macular degeneration (AMD) is a degenerative disease of the macula,
often leading to progressive vision loss. The rate of disease progression can vary among …

Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Corneal transplantation

DTH Tan, JKG Dart, EJ Holland, S Kinoshita - The Lancet, 2012 - thelancet.com
Corneal transplantation or keratoplasty has developed rapidly in the past 10 years.
Penetrating keratoplasty, a procedure consisting of full-thickness replacement of the cornea …

Age-related macular degeneration

LS Lim, P Mitchell, JM Seddon, FG Holz, TY Wong - The Lancet, 2012 - thelancet.com
Age-related macular degeneration is a major cause of blindness worldwide. With ageing
populations in many countries, more than 20% might have the disorder. Advanced age …

[HTML][HTML] Progression from early/intermediate to advanced forms of age-related macular degeneration in a large UK cohort: rates and risk factors

U Chakravarthy, CC Bailey, PH Scanlon… - Ophthalmology …, 2020 - Elsevier
Purpose To estimate rates and risk factors for progression to geographic atrophy (GA) or
choroidal neovascularization (CNV) among eyes diagnosed with early or intermediate age …

[HTML][HTML] Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: implications for age-related …

MC Marazita, A Dugour, MD Marquioni-Ramella… - Redox biology, 2016 - Elsevier
Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration
(AMD), a multifactorial disease that includes age, gene variants of complement regulatory …

A systematic review of carotenoids in the management of age-related macular degeneration

DW Lem, PG Davey, DL Gierhart, RB Rosen - Antioxidants, 2021 - mdpi.com
Age-related macular degeneration (AMD) remains a leading cause of modifiable vision loss
in older adults. Chronic oxidative injury and compromised antioxidant defenses represent …

Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study

F Jonasson, DE Fisher, G Eiriksdottir, S Sigurdsson… - Ophthalmology, 2014 - Elsevier
Objective To investigate the incidence and progression of age-related macular degeneration
(AMD) and associated risk factors. Design Population-based, prospective, cohort study …

Is age‐related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment

CMG Cheung, TY Wong - Journal of internal medicine, 2014 - Wiley Online Library
Age‐related macular degeneration (AMD) is a common vision‐threatening condition
affecting the elderly. AMD shares common risk factors and processes, including vascular …