Affective disorders including major depressive disorder (MDD), bipolar disorder (BPD), and
general anxiety affect more than 10% of population in the world. Notably, neuronal nitric …

Studies about the pathogenesis of mood disorders have consistently shown that multiple
factors, including genetic and environmental, play a crucial role on their development and …

Millions of individuals worldwide suffers from mood disorders, especially major depressive
disorder (MDD), which has a high rate of disease burden in society. Although targeting the …

Doxycycline is an antibiotic that has shown neuroprotective, anti-inflammatory, and
antidepressant-like effects. Low doses of doxycycline revert the behavioral and …

Exposure to psychological/mental stress can affect urinary function, and lead to and
exacerbate lower urinary tract dysfunctions. There is increasing evidence showing stress …

Mood disorders are chronic, recurrent mental diseases that affect millions of individuals
worldwide. Although over the past 40 years the biogenic amine models have provided …

Marked heterogeneity in suicide attempters has been observed, with earlier onset being
linked to stronger heritability, more childhood maltreatment. Nitric oxide signalling system …

The present study was designed to determine the antidepressant like activity of ascorbic
acid (AA) in mice. Further the influence of NO-sGC-cGMP signaling in the antidepressant …

It has been postulated that the activation of NMDA receptors (NMDAr) and nitric oxide (NO)
production in the hippocampus is involved in the behavioral consequences of stress. Stress …

Background Cocaine use disorder (CUD) remains a severe health problem with no effective
pharmacological therapy. One of the potential pharmacological strategies for CUD …