The general structural features of the motor region of myosin superfamily members are now
well established, as is a subset of the structural and kinetic transitions of the actin-myosin …

Receptor-ligand bonds strengthened by tensile mechanical force are referred to as catch
bonds. This review examines experimental data and biophysical theory to analyze why …

Publisher Summary This chapter describes the analysis of the polymorphism of the myosin
crossbridge and relates it to the Lymn–Taylor crossbridge cycle. Myosin from muscle …

Books dealing with the mechanisms of enzymatic reactions were written a generation ago.
They included volumes entitled Bioorganic Mechanisms, I and II by TC Bruice and SJ …

The sarcomere is an exquisitely designed apparatus that is capable of generating force,
which in the case of the heart results in the pumping of blood throughout the body. At the …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

The Escherichia coli fimbrial adhesive protein, FimH, mediates shear-dependent binding to
mannosylated surfaces via force-enhanced allosteric catch bonds, but the underlying …

Situs is a modular and widely used software package for the integration of biophysical data
across the spatial resolution scales. It has been developed over the last decade with a focus …

Catch bonds are bonds between a ligand and its receptor that are enhanced by mechanical
force pulling the ligand-receptor complex apart. To date, catch-bond formation has been …

Abstract Here we solve a 2.4-Å structure of a truncated version of the reverse-direction
myosin motor, myosin VI, that contains the motor domain and binding sites for two …