In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

Oxidative stress and reactive oxygen species (ROS) are common to many fundamental
responses of plants. Enormous and ever‐growing interest has focused on this research …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …

In-cell NMR spectroscopy provides precious structural and functional information on
biological macromolecules in their native cellular environment at atomic resolution …

Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in
copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the …

Classical structural biology approaches allow structural characterization of biological
macromolecules in vitro, far from their physiological context. Nowadays, thanks to the wealth …

Abstract Superoxide dismutase-1 (SOD1) mutants, including those with unaltered enzymatic
activity, are known to cause amyotrophic lateral sclerosis (ALS). Several destabilizing factors …