The transcription factor and oncoprotein MYC is a potent driver of many human cancers and
can regulate numerous biological activities that contribute to tumorigenesis. How a single …

Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a 5-year
survival rate of< 10%. The tumour microenvironment (TME) of PDAC is characterized by …

ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

Although RAS was formerly considered undruggable, various agents that inhibit RAS or
specific RAS oncoproteins have now been developed. Indeed, the importance of directly …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Over the past decade, RAS oncogenic proteins have transitioned from being deemed
undruggable to having two clinically approved drugs, with several more in advanced stages …

We performed comprehensive proteogenomic characterization of small cell lung cancer
(SCLC) using paired tumors and adjacent lung tissues from 112 treatment-naive patients …

Transcriptional deregulation is a hallmark of many cancers and is exemplified by genomic
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid …

c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCFFbw7
ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron …