Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine
5′-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible …

Fluoroalkyl fragments have played a critical role in the design of pharmaceutical and
agrochemical molecules in recent years due to the enhanced biological properties of …

1, 3, 5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen
heterocyclic compounds that play an important role in anticancer drug design and …

Class I phosphoinositide 3-kinases (PI3Ks) control cellular growth, but are also essential in
insulin signaling and glucose homeostasis. Pan-PI3K inhibitors thus generate substantial …

A series of novel substituted triazines bearing a benzimidazole scaffold were designed and
synthesized based on the structures of known anti-cancer agents, namely gedatolisib and …

This study describes the synthesis of novel 1, 3, 5-triazine derivatives as potent inhibitors of
cervical cancer. The compounds were initially tested for inhibition of PI3K/mTOR, where they …

A (series) range of potential dimorpholinoquinazoline-based inhibitors of the PI3K/Akt/mTOR
cascade was synthesized. Several compounds exhibited cytotoxicity towards a panel of …

The development of inhibitors targeting the PI3K-Akt-mTOR signaling pathway has been
greatly hindered by the on-target AEs, such as hyperglycemia and hepatotoxicities. In this …