A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-
zygotic transition,. However, the identity of transcription factors that underlie mammalian …

The oocyte epigenome plays critical roles in mammalian gametogenesis and
embryogenesis. Yet, how it is established remains elusive. Here, we report that histone …

Fertilization triggers assembly of higher‐order chromatin structure from a condensed
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops …

Cell identity is determined by specific gene expression patterns that are conveyed by
interactions between transcription factors and DNA in the context of chromatin. In …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Zygotic genome activation (ZGA) is essential for early embryonic development. However, the
regulation of ZGA remains elusive in mammals. Here we report that a maternal factor TDP …

In mice, transcription initiates at the mid-one-cell stage and transcriptional activity
dramatically increases during the two-cell stage, a process called zygotic gene activation …

Maternal effect genes produce mRNA or proteins that accumulate in the egg during
oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal …