G-protein–coupled receptors in heart disease
GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …
physiological role in the regulation of cardiac function in both health and disease and thus …
How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete
understanding of how they signal through 16 non-visual G-protein signal transducers …
understanding of how they signal through 16 non-visual G-protein signal transducers …
Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
G protein–coupled receptor signaling: new insights define cellular nanodomains
G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …
family and are involved in the regulation of most cell functions. Most of them reside …
Adrenergic nervous system in heart failure: pathophysiology and therapy
Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …
The interplay between autonomic nervous system and inflammation across systemic autoimmune diseases
C Bellocchi, A Carandina, B Montinaro… - International journal of …, 2022 - mdpi.com
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The
ANS regulates both innate and adaptive immunity through the sympathetic and …
ANS regulates both innate and adaptive immunity through the sympathetic and …
High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β2-Adrenergic Receptor/Gi–Dependent Manner: A New Model of Takotsubo …
Background—Takotsubo cardiomyopathy is an acute heart failure syndrome characterized
by myocardial hypocontractility from the mid left ventricle to the apex. It is precipitated by …
by myocardial hypocontractility from the mid left ventricle to the apex. It is precipitated by …
Pathophysiology of T akotsubo syndrome–a joint scientific statement from the Heart Failure Association T akotsubo Syndrome Study Group and Myocardial Function …
This is the first part of a scientific statement from the Heart Failure Association (HFA) of the
European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome …
European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome …
[HTML][HTML] Autonomic nervous system and immune system interactions
MJ Kenney, CK Ganta - Comprehensive physiology, 2014 - ncbi.nlm.nih.gov
The present review assesses the current state of literature defining integrative autonomic-
immune physiological processing, focusing on studies that have employed …
immune physiological processing, focusing on studies that have employed …