A conformal TOF–DOI Prism‐PET prototype scanner for high‐resolution quantitative neuroimaging

X Zeng, Z Wang, W Tan, E Petersen, X Cao… - Medical …, 2023 - Wiley Online Library
Background Positron emission tomography (PET) has had a transformative impact on
oncological and neurological applications. However, still much of PET's potential remains …

High-resolution depth-encoding PET detector module with prismatoid light-guide array

A LaBella, X Cao, E Petersen, R Lubinsky… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Depth-encoding detectors with single-ended readout provide a practical, cost-effective
approach for constructing high-resolution and high-sensitivity PET scanners. However, the …

Depth of interaction and coincidence time resolution characterization of ultrahigh resolution time-of-flight prism-PET modules

X Cao, A Labella, X Zeng, W Zhao… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
Depth-of-interaction (DOI) positron emission tomography (PET) detector with time-of-flight
(TOF) readout has been developed in recent years. With DOI, PET scanner could achieve …

Sub‐2 mm depth of interaction localization in PET detectors with prismatoid light guide arrays and single‐ended readout using convolutional neural networks

A LaBella, X Cao, X Zeng, W Zhao… - Medical physics, 2021 - Wiley Online Library
Purpose Depth of interaction (DOI) readout in PET imaging has been researched in efforts to
mitigate parallax error, which would enable the development of small diameter, high …

High‐resolution and high‐sensitivity PET for quantitative molecular imaging of the monoaminergic nuclei: A GATE simulation study

Z Wang, X Cao, A LaBella, X Zeng, A Biegon… - Medical …, 2022 - Wiley Online Library
Purpose Quantitative in vivo molecular imaging of fine brain structures requires high‐spatial
resolution and high‐sensitivity. Positron emission tomography (PET) is an attractive …

Resolving inter-crystal scatter in a light-sharing depth-encoding PET detector

E Petersen, A LaBella, Y Li, Z Wang… - Physics in Medicine & …, 2024 - iopscience.iop.org
Objective. Inter-crystal scattering (ICS) in light-sharing positron emission tomography (PET)
detectors leads to ambiguity in positioning the initial interaction, which significantly degrades …

Single-ended readout depth-of-interaction measurements based on random forest algorithm

R Cheng, F Wang, S Li, X Li, Y Liu… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
The depth-of-interaction (DOI) information can reduce parallax errors and improve the
spatial resolution of positron emission tomography (PET) imaging. Current DOI detectors …

Toward 100 ps coincidence time resolution using multiple timestamps in depth-encoding PET modules: A Monte Carlo simulation study

A LaBella, S Tavernier, C Woody… - … on Radiation and …, 2020 - ieeexplore.ieee.org
Coincidence time resolution (CTR) in modern time-of-flight (TOF) PET scanners is limited by
properties of the detector system, namely scintillator size and material, as well as single …

Interleaved signal multiplexing readout in depth encoding prism‐PET detectors

Y Li, A LaBella, X Zeng, Z Wang, E Petersen… - Medical …, 2023 - Wiley Online Library
Background Given the large number of readout pixels in clinical positron emission
tomography (PET) scanners, signal multiplexing is an indispensable feature to reduce …

Optimized crystal surface treatment for crosshair light-sharing TOF-DOI PET detector

E Yoshida, HG Kang, F Obata… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
The coincidence resolving time (CRT) and depth-of-interaction (DOI) resolution of PET
detectors are affected by the crystal surface treatment and the reflective material, and it is …