Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …

Transcriptional heterogeneity due to plasticity of the epigenetic state of chromatin
contributes to tumour evolution, metastasis and drug resistance,–. However, the …

To separate causal effects of histone acetylation on chromatin accessibility and
transcriptional output, we used integrated epigenomic and transcriptomic analyses following …

Mammalian chromosomes are three-dimensional entities shaped by converging and
opposing forces. Mitotic cell division induces marked chromosome condensation, but …

For cells to initiate and sustain a differentiated state, it is necessary that a 'memory'of this
state is transmitted through mitosis to the daughter cells,–. Mammalian switch/sucrose non …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Histone acetylation is important for the activation of gene transcription but little is known
about its direct read/write mechanisms. Here, we report cryogenic electron microscopy …