Candida parapsilosis Virulence and Antifungal Resistance Mechanisms: A Comprehensive Review of Key Determinants

J Branco, IM Miranda, AG Rodrigues - Journal of Fungi, 2023 - mdpi.com
Candida parapsilosis is the second most common Candida species isolated in Asia,
Southern Europe, and Latin America and is often involved in invasive infections that …

Candida parapsilosis: from genes to the bedside

R Tóth, J Nosek, HM Mora-Montes… - Clinical microbiology …, 2019 - Am Soc Microbiol
Patients with suppressed immunity are at the highest risk for hospital-acquired infections.
Among these, invasive candidiasis is the most prevalent systemic fungal nosocomial …

Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function

LL Hoyer, E Cota - Frontiers in microbiology, 2016 - frontiersin.org
Approximately two decades have passed since the description of the first gene in the
Candida albicans ALS (agglutinin-like sequence) family. Since that time, much has been …

Candida–Epithelial Interactions

JP Richardson, J Ho, JR Naglik - Journal of fungi, 2018 - mdpi.com
A plethora of intricate and dynamic molecular interactions occur between microbes and the
epithelial cells that form the mucosal surfaces of the human body. Fungi, particularly species …

Opportunistic yeast pathogen Candida spp.: Secreted and membrane-bound virulence factors

SJ Lim, MS Mohamad Ali, S Sabri… - Medical …, 2021 - academic.oup.com
Candidiasis is a fungal infection caused by Candida spp. especially Candida albicans, C.
glabrata, C. parapsilosis and C. tropicalis. Although the medicinal therapeutic strategies …

The Flo adhesin family

RG Willaert, Y Kayacan, B Devreese - Pathogens, 2021 - mdpi.com
The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen
to host tissue cells or abiotic surfaces such as catheters and implants. One of the main …

Bibliometric analysis and thematic review of Candida pathogenesis: Fundamental omics to applications as potential antifungal drugs and vaccines

SJ Lim, ND Muhd Noor, S Sabri… - Medical …, 2024 - academic.oup.com
Invasive candidiasis caused by the pathogenic Candida yeast species has resulted in
elevating global mortality. The pathogenicity of Candida spp. is not only originated from its …

Agglutinin-Like Sequence (ALS) Genes in the Candida parapsilosis Species Complex: Blurring the Boundaries Between Gene Families That Encode Cell-Wall …

SH Oh, B Smith, AN Miller, B Staker, C Fields… - Frontiers in …, 2019 - frontiersin.org
The agglutinin-like sequence (Als) proteins are best-characterized in Candida albicans and
known for their role in adhesion of the fungal cell to host and abiotic surfaces. ALS …

Gene editing in clinical isolates of Candida parapsilosis using CRISPR/Cas9

L Lombardi, SA Turner, F Zhao, G Butler - Scientific reports, 2017 - nature.com
Candida parapsilosis is one of the most common causes of candidiasis, particularly in the
very young and the very old. Studies of gene function are limited by the lack of a sexual …

Using Genomics to Shape the Definition of the Agglutinin-Like Sequence (ALS) Family in the Saccharomycetales

SH Oh, K Schliep, A Isenhower… - Frontiers in Cellular …, 2021 - frontiersin.org
The Candida albicans agglutinin-like sequence (ALS) family is studied because of its
contribution to cell adhesion, fungal colonization, and polymicrobial biofilm formation. The …