The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …

Primary cilia organize Hedgehog signaling and shape embryonic development, and their
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic …

Protein complexes are assemblies of subunits that have co-evolved to execute one or many
coordinated functions in the cellular environment. Functional annotation of mammalian …

To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-
wide screens to identify positive and negative pathway components and validated top hits …

Intracellular Ca 2+ signals are temporally controlled and spatially restricted. Signaling
occurs adjacent to sites of Ca 2+ entry and/or release, where Ca 2+-dependent effectors and …

The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial
symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling …

Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

Centrioles are microtubule-based structures crucial for forming flagella, cilia and
centrosomes. Through these roles, centrioles are critical notably for proper cell motility …

Centriole integrity, vital for cilia formation and chromosome segregation, is crucial for human
health. The inner scaffold within the centriole lumen composed of the proteins POC1B …