The T-box gene family: emerging roles in development, stem cells and cancer
VE Papaioannou - Development, 2014 - journals.biologists.com
The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …
Limb development: a paradigm of gene regulation
The limb is a commonly used model system for developmental biology. Given the need for
precise control of complex signalling pathways to achieve proper patterning, the limb is also …
precise control of complex signalling pathways to achieve proper patterning, the limb is also …
Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System
R Arora, RJ Metzger, VE Papaioannou - PLoS genetics, 2012 - journals.plos.org
Normal development of the respiratory system is essential for survival and is regulated by
multiple genes and signaling pathways. Both Tbx4 and Tbx5 are expressed throughout the …
multiple genes and signaling pathways. Both Tbx4 and Tbx5 are expressed throughout the …
Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review
IM Orioli, E Amar, J Arteaga‐Vazquez… - American Journal of …, 2011 - Wiley Online Library
Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are
replaced by a single midline limb. This study describes the prevalence, associated …
replaced by a single midline limb. This study describes the prevalence, associated …
Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina
Multipotent retinal progenitor cells (RPCs) generate various cell types in a precise
chronological order, but how exactly cone photoreceptor production is restricted to early …
chronological order, but how exactly cone photoreceptor production is restricted to early …
Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus
The study of homeotic-transformation mutants in model organisms such as Drosophila
revolutionized the field of developmental biology, but how these mutants relate to human …
revolutionized the field of developmental biology, but how these mutants relate to human …
Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder
N Liu, K Schoch, X Luo, LDM Pena… - Human molecular …, 2018 - academic.oup.com
The 17 genes of the T-box family are transcriptional regulators that are involved in all stages
of embryonic development, including craniofacial, brain, heart, skeleton and immune …
of embryonic development, including craniofacial, brain, heart, skeleton and immune …
Regulation of limb bud initiation and limb‐type morphology
V Duboc, MPO Logan - Developmental Dynamics, 2011 - Wiley Online Library
While the paired forelimb and hindlimb buds of vertebrates are initially morphologically
homogeneous, as the limb progenitors differentiate, each individual tissue element attains a …
homogeneous, as the limb progenitors differentiate, each individual tissue element attains a …
Global gene expression analysis of murine limb development
Detailed information about stage-specific changes in gene expression is crucial for
understanding the gene regulatory networks underlying development and the various signal …
understanding the gene regulatory networks underlying development and the various signal …
Character trees from transcriptome data: origin and individuation of morphological characters and the so‐called “species signal”
We elaborate a framework for investigating the evolutionary history of morphological
characters. We argue that morphological character trees generated by phylogenetic analysis …
characters. We argue that morphological character trees generated by phylogenetic analysis …