Purpose This review provides an update on the current clinical, epidemiological and
pathophysiological evidence alongside the diagnostic, prevention and treatment approach …

Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …

SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of
nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian …

In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …

Bell's palsy is the most common condition involving a rapid and unilateral onset of
peripheral paresis/paralysis of the seventh cranial nerve. It affects 11.5–53.3 per 100,000 …

Axonal degeneration is an early and prominent feature of many neurological disorders.
SARM1 is the central executioner of the axonal degeneration pathway that culminates in …

Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …

Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Brain function requires a constant supply of glucose. However, the brain has no known
energy stores, except for glycogen granules in astrocytes. In the present study, we report that …

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …