Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a
century. It has also generated considerable biomedical interest not only because of its …

Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related
decline in physiological capacity and are resistant to age-related diseases. However, it has …

It has been suggested that highly social mammals, such as naked mole rats and humans,
are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot …

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …

Analogies between placentation, in particular the behavior of trophoblast cells, and cancer
have been noted since the beginning of the twentieth century. To what degree these can be …

Hyaluronan (HA) is a simple but diverse glycosaminoglycan. It plays a major role in aging,
cellular senescence, cancer, and tissue homeostasis. In which way HA affects the …

Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can
survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary …