General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

Analysis of macromolecular/small-molecule binding pockets can provide important insights
into molecular recognition and receptor dynamics. Since its release in 2011, the POVME …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it
maintains various neuronal functions including (but not limited to) learning and memory. In …

A novel series of dinitrophenylpyrazole bearing triazole scaffolds were designed and
synthesized with appreciable yields. The structures of all the target molecules (9a–j) were …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Nicotinic acetylcholine receptors (nAChRs) are expressed widely in the CNS, and mediate
both synaptic and perisynaptic activities of endogenous cholinergic inputs and …

Given their therapeutic activity, natural products have been used in traditional medicines
throughout the centuries. The growing interest of the scientific community in …

Pentameric ligand-gated ion channels (pLGICs) play a central role in synaptic
communication and are implicated in a plethora of neurological disorders leading to human …