Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of
lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly …

Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded
unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells …

Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …

The T cells of the immune system can target tumors and clear solid cancers following tumor-
infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a …

Many tumors overexpress tumor-associated antigens relative to normal tissue, such as
EGFR. This limits targeting by human T cells modified to express chimeric antigen receptors …

This review provides insight into the role of engineered T-cell receptors (TCRs) in
immunotherapy. Novel approaches have been developed to boost anticancer immune …

Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell receptor
(TCR) has shown significant therapeutic potential for both hematological and solid tumors …

T-cell receptor–engineered T-cell therapy and chimeric antigen receptor T-cell therapy are 2
types of adoptive T-cell therapy that genetically modify natural T cells to treat cancers …

A major challenge in adoptive T cell immunotherapy is the discovery of natural T cell
receptors (TCRs) with high activity and specificity to tumor antigens. Engineering synthetic …

T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) …