The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine

JD Salamone, M Correa - Annual Review of Psychology, 2024 - annualreviews.org
Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …

Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

JD Salamone, SE Yohn, L López-Cruz, N San Miguel… - Brain, 2016 - academic.oup.com
Motivation has been defined as the process that allows organisms to regulate their internal
and external environment, and control the probability, proximity and availability of stimuli. As …

Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence

S Wang, F Leri, SJ Rizvi - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

[HTML][HTML] Caffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression

L López-Cruz, JD Salamone, M Correa - Frontiers in pharmacology, 2018 - frontiersin.org
Major depressive disorder is one of the most common and debilitating psychiatric disorders.
Some of the motivational symptoms of depression, such anergia (lack of self-reported …

[HTML][HTML] Apathy as a treatment target in Alzheimer's disease: implications for clinical trials

ME Mortby, L Adler, L Agüera-Ortiz, DR Bateman… - The American Journal of …, 2022 - Elsevier
Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across
the neurocognitive disorders spectrum. Recent advances in understanding of …

A specific role for serotonin in overcoming effort cost

F Meyniel, GM Goodwin, JFW Deakin, C Klinge… - Elife, 2016 - elifesciences.org
Serotonin is implicated in many aspects of behavioral regulation. Theoretical attempts to
unify the multiple roles assigned to serotonin proposed that it regulates the impact of costs …

Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to …

C Carratalá-Ros, A Martínez-Verdú… - …, 2023 - Springer
Background Depression is a disorder twice as common in women than in men. There are
sex differences in the symptomatology and treatment response to this disorder. Impairments …

Not all antidepressants are created equal: differential effects of monoamine uptake inhibitors on effort-related choice behavior

SE Yohn, SL Collins, HM Contreras-Mora… - …, 2016 - nature.com
Motivated behavior can be characterized by behavioral activation and high work output.
Moreover, people with depression and other disorders show effort-related motivational …

Neurobiological basis of motivational deficits in psychopathology

JD Salamone, I Koychev, M Correa… - European …, 2015 - Elsevier
In recent years, there has been increasing emphasis on the importance of motivational
symptoms in depression, schizophrenia and other disorders. The present review discusses …

Apathy in late-life depression: common, persistent, and disabling

GS Yuen, S Bhutani, BJ Lucas, FM Gunning… - The American Journal of …, 2015 - Elsevier
Objective The aims of this study were to examine:(1) the relationship between apathy and
disability in late-life depression, and (2) the functional significance of improvement in apathy …