Natural products can generally exhibit a variety of biological activities, but most show
mediocre performance in preliminary activity evaluation. Natural products often require …

Abstract β-Carboline alkaloids are an eminent class of nitrogen-based natural alkaloids and
therapeutic molecules which exert various pharmacological activities through diverse …

Thirty novel dioxolane ring compounds were designed and synthesized. Their chemical
structures were confirmed by 1H NMR, HRMS, and single crystal X-ray diffraction analysis …

Malaria remains one of the major health problems worldwide. The lack of an effective
vaccine and the increasing resistance of Plasmodium to the approved antimalarial drugs …

Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …

Cancer and malaria are both global health threats. Due to the increase in the resistance to
the known drugs, research on new active substances is a priority. Here, we present the …

Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public
health threat. The development of antimalarial drug resistance is reversing the gains made …

Inhibiting quorum sensing (QS), a central communication system, is a promising strategy to
combat bacterial pathogens without antibiotics. Here, we designed novel hybrid compounds …

Malaria, one of the oldest parasitic diseases, remains a global health threat, and the
increasing resistance of the malaria parasite to current antimalarials is forcing the discovery …

Halohydrin dehalogenases (HHDHs) possess an unnatural activity of introducing
functionalities such as N3, CN, NO2 etc., into a molecule through the ring‐opening reaction …