Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

This review attempts to give a concise and up-to-date overview on the role of potassium
channels in epilepsies. Their role can be defined from a genetic perspective, focusing on …

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration
and considered as an endoplasmic reticulum (ER) disease. Despite the underlying …

Purpose Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for
the formation of aromatic C–18 F bonds. This minireview examines proof-of-concept …

Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

Beckwith–Wiedemann syndrome (BWS) is the most common (epi) genetic overgrowth-
cancer predisposition disorder. Given the absence of consensual recommendations or …

Insulin secretion from pancreatic β-cells is tightly regulated to keep fasting blood glucose
concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia …

Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis
and treatment, it was considered necessary to formulate evidence-based clinical practice …

A one-pot two-step synthesis of 6-[18F] fluoro-L-DOPA ([18F] FDOPA) has been developed
involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method …

Background/aims Congenital hyperinsulinism (CHI) is a heterogeneous disease most
frequently caused by KATP-channel (ABCC8 and KCNJ11) mutations, with neonatal or later …