Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …

The hallmarks of cancer include multiple alterations in the physiological processes occurring
in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These …

The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine
kinase receptors, yet its biological functions and activation mechanisms are still not fully …

Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein
member of the Semaphorin family. Semaphorins were first identified as chemorepellants that …

Resistance to anti-androgen therapy for metastatic prostate cancer is a major clinical
problem. Sema3C promotes resistance to androgen withdrawal via its receptor, PlexinB1 …

The semaphorins were initially characterized as repulsive axon guidance factors. However,
they are currently also recognized as important regulators of diverse biological processes …

Semaphorins are extracellular signals known to guide migrating cells during developmental
morphogenesis and in adult tissues. Semaphorin receptors, that is plexins and neuropilins …

Metastatic prostate cancer is essentially incurable and is a leading cause of cancer-related
morbidity and mortality in men, yet the underlying molecular mechanisms are poorly …