Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and
a key player in cancer metabolism. This review is aimed at combining the mechanisms …

This review focuses on the evolving understanding that we have of tumor cell metabolism,
particularly glycolytic and oxidative metabolism, and traces back its evolution through time …

Cell-based therapy is a promising strategy in regenerative medicine, but the poor survival
rate of the implanted cells remains a major challenge and limits clinical translation. We …

Glucose plays a central role in tumor metabolism and development and is a target for novel
therapeutics. To characterize the response of cancer cells to blockade of glucose uptake, we …

Cancer metabolism has received renewed interest as a potential target for cancer therapy. In
this study, we use a multi-scale modeling approach to interrogate the implications of three …

Reprogramming of energy metabolism is a hallmark of cancer that enables the cancer cells
to meet the increased energetic requirements due to uncontrolled proliferation. One …

Mathematical modeling provides the predictive ability to understand the metabolic
reprogramming and complex pathways that mediate cancer cells' proliferation. We present a …

We present the development and validation of a mathematical model that predicts how
glucose dynamics influence metabolism and therefore tumor cell growth. Glucose, the …

Cell‐intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic
support to cell proliferation. How reprogramming influences tumor heterogeneity or drug …

Cancer cells metabolism focuses the interest of the cancer research community. Although
this process is intensely studied experimentally, there are very few theoretical models that …