Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Most membrane proteins are synthesized on endoplasmic reticulum (ER)-bound ribosomes
docked at the translocon, a heterogeneous ensemble of transmembrane factors operating …

Functional genomics efforts face tradeoffs between number of perturbations examined and
complexity of phenotypes measured. We bridge this gap with Perturb-seq, which combines …

Cellular functions are mediated by protein–protein interactions, and mapping the
interactome provides fundamental insights into biological systems. Affinity purification …

Although artificial neural networks are powerful classifiers, their internal structures are hard
to interpret. In the life sciences, extensive knowledge of cell biology provides an opportunity …

The organization of a cell emerges from the interactions in protein networks. The
interactome is critically dependent on the strengths of interactions and the cellular …

Seminal yeast studies have established the value of comprehensively mapping genetic
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …

The unfolded protein response (UPR) is a conserved homeostatic program that is activated
by misfolded proteins in the lumen of the endoplasmic reticulum (ER). Recently, it became …