The role of Nrf2 in the antioxidant cellular response to medical ozone exposure

M Galiè, V Covi, G Tabaracci, M Malatesta - International Journal of …, 2019 - mdpi.com
Ozone (O3) is a natural, highly unstable atmospheric gas that rapidly decomposes to
oxygen. Although not being a radical molecule, O3 is a very strong oxidant and therefore it is …

[HTML][HTML] Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

C Scassellati, AC Galoforo, C Bonvicini… - Ageing Research …, 2020 - Elsevier
Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 …

S Gencer, C Gür, M İleritürk, S Küçükler… - … of biochemical and …, 2024 - Wiley Online Library
Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in
the body is the liver. Carvacrol is a natural phytocompound that stands out with its …

Ozone therapy as adjuvant for cancer treatment: is further research warranted?

B Clavo, N Santana-Rodríguez… - Evidence‐Based …, 2018 - Wiley Online Library
Introduction. This article provides an overview of the potential use of ozone as an adjuvant
during cancer treatment. Methods. We summarize the findings of the most relevant …

Insights on the mechanisms of action of ozone in the medical therapy against COVID-19

S Chirumbolo, L Valdenassi, V Simonetti… - International …, 2021 - Elsevier
An increasing amount of reports in the literature is showing that medical ozone (O 3) is used,
with encouraging results, in treating COVID-19 patients, optimizing pain and symptoms …

[HTML][HTML] Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment

C Scassellati, M Ciani, AC Galoforo, R Zanardini… - Mechanisms of ageing …, 2020 - Elsevier
In the last decade, cognitive frailty has gained great attention from the scientific community. It
is characterized by high inflammation and oxidant state, endocrine and metabolic …

Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy

J Sha, B Sui, X Su, Q Meng… - Molecular Medicine …, 2017 - spandidos-publications.com
Diabetic nephropathy (DN) is one of the most significant long‑term complications in terms of
morbidity and mortality for diabetic patients; however, the exact cause remains unknown. To …

MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3

J Lou, Y Wang, Z Zhang, W Qiu - Experimental cell research, 2017 - Elsevier
Tuberculosis (TB) is one of immune-related disorders. Although dysregulation of miRNAs
has been implicated in innate and adaptive immune response, the specific effect of miR-20b …

Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and …

NA Kankılıç, H Şimşek, N Akaras, C Gür… - … of Biochemical and …, 2024 - Wiley Online Library
Antimicrobial agent resistance has become a growing health issue across the world. Colistin
(COL) is one of the drugs used in the treatment of multidrug‐resistant bacteria resulting in …

Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats

E Saglam, SB Alinca, TZ Celik… - Journal of applied oral …, 2019 - SciELO Brasil
Objective: The goal of the present study was to determine the effect of systemic and topical
ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible …