Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

ABSTRACT Introduction: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes
acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline …

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
around the world. Even though the causes of AD are not completely understood due to its …

Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …

The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ)
peptides has attracted a lot of attention in recent years due to its repercussions in …

Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative illness, which
involves the progressive deterioration of intellectual functions and behavioral disorders …

The complications of Alzheimer's disease AD were deadly dangerous cause of
neurodegenerative disorders connected with the decline of the cognitive functions and loss …

We have synthesized a family of rhein–huprine hybrids to hit several key targets for
Alzheimer's disease. Biological screening performed in vitro and in Escherichia coli cells …