Oxygenated polyunsaturated fatty acids (oxylipins) are bioactive molecules established as
important mediators during inflammation. Different classes of oxylipins have been found to …

Oxylipins are potent lipid mediators with increasing interest in clinical research. They are
usually measured in systemic circulation and can provide a wealth of information regarding …

Systemic inflammation has been implicated in the pathobiology of heart failure with
preserved ejection fraction (HFpEF). Here, we examine the association of upstream …

Abstract Serum ceramides, especially C16: 0 and C18: 0 species, are linked to CVD risk and
insulin resistance, but details of this association are not well understood. We performed this …

Type 2 diabetes (T2D) and hypertension (HTN) are common risk factors of cardiovascular
diseases (CVD) characterized by chronic low-grade systemic inflammation and impaired …

Background Obesity drives maladaptive changes in the white adipose tissue (WAT) which
can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic …

Abstract Angiotensin-converting enzyme 2 (ACE2) polymorphisms are associated with
increased risk of type 2 diabetes mellitus (T2DM), obesity and dyslipidemia, which have …

Arachidonic acid (AA) metabolites have been associated with several diseases across
various organ systems, including the cardiovascular, pulmonary, and renal systems. Lipid …

The clinical blood metabogram (CBM) was developed to match a tailored analysis of the
blood metabolome to the time, cost, and reproducibility constraints of clinical laboratory …

Abstract Background & Aims: Chronic inflammation associated with obesity directly
contributes to metabolic comorbidities, including type 2 diabetes (T2D). Roux-en-Y gastric …