The complement system in schizophrenia: where are we now and what's next?
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …
pathogens and removal of waste materials. Recent evidence has implicated the complement …
Complement system in brain architecture and neurodevelopmental disorders
J Magdalon, F Mansur, AL Teles e Silva… - Frontiers in …, 2020 - frontiersin.org
Current evidence indicates that certain immune molecules such as components of the
complement system are directly involved in neurobiological processes related to brain …
complement system are directly involved in neurobiological processes related to brain …
Long neural genes harbor recurrent DNA break clusters in neural stem/progenitor cells
Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for
neural development, and brain cells frequently contain somatic genomic variations that …
neural development, and brain cells frequently contain somatic genomic variations that …
Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions
C Zhuo, H Tian, X Song, D Jiang, G Chen, Z Cai… - Schizophrenia, 2023 - nature.com
Cognitive impairment is a core clinical feature of schizophrenia, exerting profound adverse
effects on social functioning and quality of life in a large proportion of patients with …
effects on social functioning and quality of life in a large proportion of patients with …
[HTML][HTML] Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders
W Song, Q Li, T Wang, Y Li, T Fan, J Zhang… - Brain, Behavior, and …, 2022 - Elsevier
Recent studies have reported that complement-related proteins modulate brain
development through regulating synapse processes in the cortex. CSMD3 belongs to a …
development through regulating synapse processes in the cortex. CSMD3 belongs to a …
Aberrant complement system activation in neurological disorders
K Ziabska, M Ziemka-Nalecz, P Pawelec… - International Journal of …, 2021 - mdpi.com
The complement system is an assembly of proteins that collectively participate in the
functions of the healthy and diseased brain. The complement system plays an important role …
functions of the healthy and diseased brain. The complement system plays an important role …
[HTML][HTML] CSMD1 regulates brain complement activity and circuit development
Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …
[HTML][HTML] A genetic association study of CSMD1 and CSMD2 with cognitive function
L Athanasiu, S Giddaluru, C Fernandes… - Brain, behavior, and …, 2017 - Elsevier
The complement cascade plays a role in synaptic pruning and synaptic plasticity, which
seem to be involved in cognitive functions and psychiatric disorders. Genetic variants in the …
seem to be involved in cognitive functions and psychiatric disorders. Genetic variants in the …
A review of molecular genetic studies of neurocognitive deficits in schizophrenia
Schizophrenia is a complex and debilitating illness with strong genetic loading. In line with
its heterogeneous symptomatology, evidence suggests genetic etiologies for the …
its heterogeneous symptomatology, evidence suggests genetic etiologies for the …
Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth
Background Increased expression of the complement component 4A (C4A) gene is
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …