Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly
accepted as a core component of carcinoma progression. Collectively, EMT and …

Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their
junctions and polarity to gain a motile mesenchymal phenotype. EMT is essential during …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

The epithelial to mesenchymal transition (EMT) is a fundamental developmental process
essential for normal embryonic development. It is also important during various pathogenic …

Abstract ETP-ALL (Early T cell Progenitor Acute Lymphoblastic Leukemia) represents a high-
risk subtype of T cell acute lymphocytic leukemia (T-ALL). Therapeutically, ETP-ALL patients …

It has become clear that cellular plasticity is a main driver of cancer therapy resistance.
Consequently, there is a need to mechanistically identify the factors driving this process. The …

Lysine specific demethylase-1 (LSD1) has been shown to be critical in acute myeloid
leukemia (AML) pathogenesis and this has led to the development of LSD1 inhibitors …